Kentucky vs South Carolina Prediction, Picks & Odds | 27 Sep 2025

College Football Betting Preview: Kentucky vs South Carolina

Kentucky battle South Carolina in this NCAAF Week 5 matchup at Williams-Brice Stadium, with kickoff scheduled for 07:45 on Sunday 28 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

South Carolina Against the Spread Look the Best Bet

Get with South Carolina with a -5.5 spread. We’re backing the favorites at 1.93 to enjoy a solid win when they go head-to-head with Kentucky.

Think our spread prediction is solid? Secure the best Stake promo code and read our full sportsbook review before placing your wager.

South Carolina Beat Kentucky in Pair’s Last Head-to-Head

Kentucky Wildcats claimed a victory in their previous game. A 48-23 home win occurred against Eastern Michigan Eagles at Kroger Field.

South Carolina Gamecocks lost on the road in their last game, making it back-to-back defeats. Missouri Tigers won 29-20 at Faurot Field.

Head-to-Head Statistics

South Carolina won the last matchup between the pair. Enjoying a 31-6 triumph when facing Kentucky at Kroger Field. In the past 6 games between the teams, South Carolina have won four.

Quarterbacks

Cutter Boley

LaNorris Sellers

Kentucky vs South Carolina Prediction & Picks

Get ready for Kentucky vs South Carolina with all the betting angles covered, from an expert match prediction and correct score advice to player props and a custom bet builder.

Game Prediction

It’s great to see South Carolina given a -5.5 line on the spread at 1.93 as we’re expecting a bigger margin of victory in this college football matchup.

Injuries can influence the outcome and our CFB handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the matchup might unfold.

Key Kentucky vs South Carolina stats:

• The -5.5 line has been covered by South Carolina in 2 of their last 3 games at home this season.
• The -5.5 line has been covered by South Carolina in 3 of their last 5 games at home.
• The +5.5 line hasn’t been covered by Kentucky in 3 consecutive games on the road.
• The +5.5 line hasn’t been covered by Kentucky in 7 of their last 10 games.

South Carolina -5.5 Probability

The top sportsbooks imply that our pick has a 51.8% prospect of winning. However, our research has found that the actual probability is closer to 60%. It's therefore regarded as a value wager.

Bigger prices can be secured for bettors who are prepared to move the line. The odds increase according to how much risk you are prepared to have with your wager.

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Best Bet

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Player Prop Picks

Correct Score Prediction

Kentucky 21 - 31 South Carolina

There is a speculative bet that can be enjoyed on South Carolina when it comes to the correct score lines. Taking them to win 31-21 should provide some entertainment.

Kentucky vs South Carolina Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

South Carolina Moneyline Odds Suggest Victory

The sportsbooks have South Carolina at 1.48 when it comes to the Moneyline betting, implying the market leaders are 68% likely to win this college game according to the latest odds. Kentucky are the underdogs at 2.72 and they’re regarded as least likely to win.

The spread is calculated to be 5.5, while total points comes in at 47.5. Football bettors regularly enjoy the opportunity to wager on the Totals. Those expecting a low total can back Under 47.5 at 1.91.

The best betting apps provide tons of game lines and team props for nearly every college football matchup. Take a few moments to browse all the markets so you can place a bet that matches your insight.

Rahsul Faison Favorite to Score First TD

Rahsul Faison is the First Touchdown Scorer favorite at 6.50. Alternatively, there’s the opportunity to simply back him to score a TD anytime at 1.83.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Micro Betting

Instead of focusing on the overall outcome, some bettors prefer to look at the college football micro betting lines. As the name suggests, it means placing short-term in-game wagers and this might include the Next Play or Next Drive Result.

South Carolina Have Picked Up Six Wins From Last Ten Home Games

South Carolina own a 6-4 mark in their past 10 home games, averaging 29.50 points on offense and surrendering 20.80 on defense.

Kentucky have fallen in three consecutive away contests. They own a 5-5 mark in their past 10 road games, averaging 22.70 points scored and 27.10 points allowed.

In their most recent matchup at Williams-Brice Stadium, South Carolina got the better of Kentucky 17-14. Across the past 3 head-to-head meetings at Williams-Brice Stadium, South Carolina have recorded two wins, with Kentucky winning once.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
South Carolina Home Stats		6-4	50.30	29.50	20.80	6	4
Kentucky Away Stats		5-5	49.80	22.70	27.10	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Kentucky Wildcats Stats

South Carolina Gamecocks Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 49.90 pts in the previous 10 games
• Game Totals on the Road: An average of 49.80 pts in the previous 10 games on the road
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.20 pts and allowed 26.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.70 pts and allowed 27.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.00 pts in the previous 10 games
• Game Totals at Home: An average of 51.50 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 28.50 pts and allowed 18.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.20 pts and allowed 20.30 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Missouri	5	0	226	73	153	5-0	0-0	5W
Oklahoma	4	0	125	36	89	3-0	1-0	4W
Ole Miss	5	0	203	94	109	4-0	1-0	5W
Texas A&M	4	0	143	96	47	3-0	1-0	4W
Vanderbilt	5	0	245	86	159	3-0	2-0	5W
LSU	4	1	135	61	74	3-0	1-1	1L
Mississippi State	4	1	193	88	105	3-1	1-0	1L
Tennessee	4	1	255	145	110	3-1	1-0	2W
Alabama	3	1	152	66	86	2-0	1-1	3W
Georgia	3	1	138	78	60	2-1	1-0	1L
Texas	3	1	127	31	96	3-0	0-1	3W
Auburn	3	2	138	82	56	2-0	1-2	2L
South Carolina	3	2	124	94	30	3-1	0-1	1W
Kentucky	2	2	108	104	4	2-1	0-1	1L
Arkansas	2	3	187	150	37	2-1	0-2	3L
Florida	1	3	88	64	24	1-1	0-2	3L